If you are flying into Prague, you may take the airport shuttle bus to reach the center of the city and then take the metro to reach your hotel. A more expensive option is to take a taxi. Best of all is going for the Private Arrival Transfer and Private Departure Transfer.

If you are arriving in the city by train, your last stop will either be Hlavní Nádrazí (Main Station) or Nádrazí Holesovice (Holesovice Station) which are both connected to the metro.

You'll then rarely need to use public transportation to get around the city, as you can simply cross the pedestrian Charles Bridge to go between the two main tourist areas of the city. But if your hotel happens to be outside the center, use the metro or the trams which cover most of the city.

If you're going elsewhere in the Czech Republic you may need to rent a car.